A critical role for endoglin in the emergence of blood during embryonic development

Much remains unknown about the signals that induce early mesoderm to initiate hematopoietic differentiation. Here, we show that endoglin (Eng), a receptor for the TGFβ superfamily, identifies all cells with hematopoietic fate in the early embryo. These arise in an Eng(+)Flk1(+) mesodermal precursor...

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Detalhes bibliográficos
Main Authors: Borges, Luciene, Iacovino, Michelina, Mayerhofer, Timothy, Koyano-Nakagawa, Naoko, Baik, June, Garry, Daniel J., Kyba, Michael, Letarte, Michelle, Perlingeiro, Rita C. R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369678/
https://ncbi.nlm.nih.gov/pubmed/22535663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391896
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