Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3. In the present study we demonstrate that PPS media...

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Bibliografske podrobnosti
Main Authors: Troeberg, Linda, Mulloy, Barbara, Ghosh, Peter, Lee, Meng-Huee, Murphy, Gillian, Nagase, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369482/
https://ncbi.nlm.nih.gov/pubmed/22299597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20112159
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