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Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis

Trop-2 is a transmembrane glycoprotein upregulated in several human carcinomas, including prostate cancer (PrCa). Trop-2 has been suggested to regulate cell-cell adhesion, given its high homology with the other member of the Trop family, Trop-1/EpCAM, and its ability to bind the tight junction prote...

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Main Authors: Trerotola, Marco, Li, Jing, Alberti, Saverio, Languino, Lucia R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369113/
https://ncbi.nlm.nih.gov/pubmed/22378065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24074
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