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The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance

Estrogen plays important roles in hormone receptor-positive breast cancer. Endocrine therapies, such as the antiestrogen tamoxifen, antagonize the binding of estrogen to estrogen receptor (ER), whereas aromatase inhibitors (AIs) directly inhibit the production of estrogen. Understanding the mechanis...

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Detalles Bibliográficos
Main Authors: Wong, Cynthie, Chen, Shiuan
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369003/
https://ncbi.nlm.nih.gov/pubmed/22265958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2011.12.005
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