Monoclonal Antibody Against the Turn of the 42-Residue Amyloid β-Protein at Positions 22 and 23

[Image: see text] Aggregation of the 42-mer amyloid β-protein (Aβ42) plays a critical role in the pathogenesis of Alzheimer’s disease (AD). We have proposed a toxic conformer with a turn at positions 22 and 23, as well as a nontoxic conformer with a turn at positions 25 and 26, in Aβ42 aggregates fr...

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Hauptverfasser: Murakami, Kazuma, Horikoshi-Sakuraba, Yuko, Murata, Nakaba, Noda, Yoshihiro, Masuda, Yuichi, Kinoshita, Noriaki, Hatsuta, Hiroyuki, Murayama, Shigeo, Shirasawa, Takuji, Shimizu, Takahiko, Irie, Kazuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368655/
https://ncbi.nlm.nih.gov/pubmed/22778811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100072e
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