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A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease

Immunotherapy targeting Aβ42 is drawing attention as a possible therapeutic approach for Alzheimer’s disease (AD). Considering the significance of reported oligomerized Aβ42 species, selective targeting of the oligomer will increase the therapeutic efficacy. However, what kinds of oligomers are suit...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Izuo, Naotaka, Kasahara, Chihiro, Murakami, Kazuma, Kume, Toshiaki, Maeda, Masahiro, Irie, Kazuhiro, Yokote, Koutaro, Shimizu, Takahiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603611/
https://ncbi.nlm.nih.gov/pubmed/28924167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11671-6
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