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A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease

Immunotherapy targeting Aβ42 is drawing attention as a possible therapeutic approach for Alzheimer’s disease (AD). Considering the significance of reported oligomerized Aβ42 species, selective targeting of the oligomer will increase the therapeutic efficacy. However, what kinds of oligomers are suit...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Izuo, Naotaka, Kasahara, Chihiro, Murakami, Kazuma, Kume, Toshiaki, Maeda, Masahiro, Irie, Kazuhiro, Yokote, Koutaro, Shimizu, Takahiko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603611/
https://ncbi.nlm.nih.gov/pubmed/28924167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11671-6
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