SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

Oxidative stress is closely linked to the pathogenesis of neurodegeneration. Soluble amyloid β (Aβ) oligomers cause cognitive impairment and synaptic dysfunction in Alzheimer disease (AD). However, the relationship between oligomers, oxidative stress, and their localization during disease progressio...

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Detalhes bibliográficos
Main Authors: Murakami, Kazuma, Murata, Nakaba, Noda, Yoshihiro, Tahara, Shoichi, Kaneko, Takao, Kinoshita, Noriaki, Hatsuta, Hiroyuki, Murayama, Shigeo, Barnham, Kevin J., Irie, Kazuhiro, Shirasawa, Takuji, Shimizu, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247976/
https://ncbi.nlm.nih.gov/pubmed/22072713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.279208
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