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Functional differences between kindlin-1 and kindlin-2 in keratinocytes

Integrin-β1-null keratinocytes can adhere to fibronectin through integrin αvβ6, but form large peripheral focal adhesions and exhibit defective cell spreading. Here we report that, in addition to the reduced avidity of αvβ6 integrin binding to fibronectin, the inability of integrin β6 to efficiently...

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Hlavní autoři: Bandyopadhyay, Aditi, Rothschild, Gerson, Kim, Sean, Calderwood, David A., Raghavan, Srikala
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367939/
https://ncbi.nlm.nih.gov/pubmed/22328497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.096214
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