PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential

Fusion protein AML1-ETO, resulting from t(8;21) translocation, is highly related to leukemia development. It has been reported that full-length AML1-ETO blocks AML1 function and requires additional mutagenic events to promote leukemia. We have previously shown that the expression of AE9a, a splice i...

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Main Authors: Shia, Wei-Jong, Okumura, Akiko J., Yan, Ming, Sarkeshik, Ali, Lo, Miao-Chia, Matsuura, Shinobu, Komeno, Yukiko, Zhao, Xinyang, Nimer, Stephen D., Yates, John R., Zhang, Dong-Er
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367897/
https://ncbi.nlm.nih.gov/pubmed/22498736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-347476
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