C/EBPα and DEK coordinately regulate myeloid differentiation

The transcription factor C/EBPα is a critical mediator of myeloid differentiation and is often functionally impaired in acute myeloid leukemia. Recent studies have suggested that oncogenic FLT3 activity disrupts wild-type C/EBPα function via phosphorylation on serine 21 (S21). Despite the apparent r...

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Detalhes bibliográficos
Main Authors: Koleva, Rositsa I., Ficarro, Scott B., Radomska, Hanna S., Carrasco-Alfonso, Marlene J., Alberta, John A., Webber, James T., Luckey, C. John, Marcucci, Guido, Tenen, Daniel G., Marto, Jarrod A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367892/
https://ncbi.nlm.nih.gov/pubmed/22474248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-383083
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