Heart repair by reprogramming non-myocytes with cardiac transcription factors

The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodeling and susceptibility to arrhythmias. Cardiac fibroblasts account f...

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Autori principali: Song, Kunhua, Nam, Young-Jae, Luo, Xiang, Qi, Xiaoxia, Tan, Wei, Huang, Guo N., Acharya, Asha, Smith, Christopher L., Tallquist, Michelle D., Neilson, Eric G., Hill, Joseph A., Bassel-Duby, Rhonda, Olson, Eric N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367390/
https://ncbi.nlm.nih.gov/pubmed/22660318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11139
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