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Heart repair by reprogramming non-myocytes with cardiac transcription factors
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodeling and susceptibility to arrhythmias. Cardiac fibroblasts account f...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367390/ https://ncbi.nlm.nih.gov/pubmed/22660318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11139 |
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