Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid

Extracellular plaques of β-amyloid (Aβ) and intraneuronal neurofibrillary tangles made from tau are the histopathological signatures of Alzheimer’s disease (AD). Plaques comprise Aβ fibrils that assemble from monomeric and oligomeric intermediates, and are prognostic indicators of AD. Despite the si...

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Hauptverfasser: Nussbaum, Justin M., Schilling, Stephan, Cynis, Holger, Silva, Antonia, Swanson, Eric, Wangsanut, Tanaporn, Tayler, Kaycie, Wiltgen, Brian, Hatami, Asa, Rönicke, Raik, Reymann, Klaus, Hutter-Paier, Birgit, Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Glabe, Charles G., Demuth, Hans-Ulrich, Bloom, George S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367389/
https://ncbi.nlm.nih.gov/pubmed/22660329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11060
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