Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During semi-conservative DNA replication, hemi-methylated (M/C) and hemi-hydroxymethylated (H/C) CpG dinucleotides are transiently generated, where only th...

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Detalhes bibliográficos
Main Authors: Hashimoto, Hideharu, Liu, Yiwei, Upadhyay, Anup K., Chang, Yanqi, Howerton, Shelley B., Vertino, Paula M., Zhang, Xing, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367191/
https://ncbi.nlm.nih.gov/pubmed/22362737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks155
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