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Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D
Actinomycin D (ActD) is a small molecule with strong antibiotic and anticancer activity. However, its biologically relevant DNA-binding mechanism has never been resolved, with some studies suggesting that the primary binding mode is intercalation, and others suggesting that single-stranded DNA bindi...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367174/ https://ncbi.nlm.nih.gov/pubmed/22328730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks069 |
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