DISRUPTION OF PURKINJE CELL FUNCTION PRIOR TO HUNTINGTIN ACCUMULATION AND CELL LOSS IN AN ANIMAL MODEL OF HUNTINGTON DISEASE

Huntington Disease (HD) is a devastating neurological disorder characterized by progressive deterioration of psychiatric, motor, and cognitive function. Purkinje cells (PCs), the output neurons of the cerebellar cortex, have been found to be vulnerable in multiple CAG repeat disorders, but little is...

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Détails bibliographiques
Auteurs principaux: Dougherty, S.E., Reeves, J. L., Lucas, E. K., Gamble, K. L., Lesort, M., Cowell, R. M.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367067/
https://ncbi.nlm.nih.gov/pubmed/22579526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.04.015
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