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Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α

Alterations in the expression and activity of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (ppargc1a or PGC-1α) have been reported in multiple movement disorders, yet it is unclear how a lack of PGC-1α impacts transcription and function of the cerebellu...

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Pubblicato in:Front Cell Neurosci
Autori principali: Lucas, Elizabeth K., Reid, Courtney S., McMeekin, Laura J., Dougherty, Sarah E., Floyd, Candace L., Cowell, Rita M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285109/
https://ncbi.nlm.nih.gov/pubmed/25610371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00441
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