Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α

Accumulating evidence implicates the transcriptional coactivator peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) in the pathophysiology of Huntington Disease (HD). Adult PGC-1α (−/−) mice exhibit striatal neurodegeneration, and reductions in the expression of PGC-1α have been ob...

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Autors principals: Lucas, Elizabeth K., Dougherty, Sarah E., McMeekin, Laura J., Trinh, Alisa T., Reid, Courtney S., Cowell, Rita M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419240/
https://ncbi.nlm.nih.gov/pubmed/22916173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042878
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