Atypical Membrane-embedded Phosphatidylinositol 3,4-Bisphosphate (PI(3,4)P(2))-binding Site on p47(phox) Phox Homology (PX) Domain Revealed by NMR

The Phox homology (PX) domain is a functional module that targets membranes through specific interactions with phosphoinositides. The p47(phox) PX domain preferably binds phosphatidylinositol 3,4-bisphosphate (PI(3,4)P(2)) and plays a pivotal role in the assembly of phagocyte NADPH oxidase. We descr...

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Detalhes bibliográficos
Main Authors: Stampoulis, Pavlos, Ueda, Takumi, Matsumoto, Masahiko, Terasawa, Hiroaki, Miyano, Kei, Sumimoto, Hideki, Shimada, Ichio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366843/
https://ncbi.nlm.nih.gov/pubmed/22493288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332874
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