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Mutations in the PX–SH3(A) Linker of p47(phox) Decouple PI(3,4)P(2) Binding from NADPH Oxidase Activation
NADPH oxidase is essential in the human innate immune response. p47(phox), a cytosolic NADPH oxidase component, plays a regulatory role in the activation of NADPH oxidase. Our manipulation of p47(phox) by mutation and amino acid deletion shows that the linker region between the PX and N-terminal SH3...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745045/ https://ncbi.nlm.nih.gov/pubmed/18672905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8005847 |
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