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Cathepsins L and Z Are Critical in Degrading Polyglutamine-containing Proteins within Lysosomes
In neurodegenerative diseases caused by extended polyglutamine (polyQ) sequences in proteins, aggregation-prone polyQ proteins accumulate in intraneuronal inclusions. PolyQ proteins can be degraded by lysosomes or proteasomes. Proteasomes are unable to hydrolyze polyQ repeat sequences, and during br...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366842/ https://ncbi.nlm.nih.gov/pubmed/22451661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352781 |
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