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The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins
The p97/VCP ATPase complex facilitates the extraction and degradation of ubiquitinated proteins from larger structures. We therefore studied if p97 participates to the rapid degradation of myofibrillar proteins during muscle atrophy. Electroporation of a dominant negative p97 (DNp97), but not the WT...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411080/ https://ncbi.nlm.nih.gov/pubmed/22773186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.178 |
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