The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)

The epithelial-mesenchymal transition (EMT) is a key step for cancer cell migration, invasion, and metastasis. Transforming growth factor-β (TGF-β) regulates the EMT and the metastasis suppressor gene, N-myc downstream-regulated gene-1 (NDRG1), could play a role in regulating the TGF-β pathway. NDRG...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Zhiqiang, Zhang, Daohai, Yue, Fei, Zheng, Minhua, Kovacevic, Zaklina, Richardson, Des R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366822/
https://ncbi.nlm.nih.gov/pubmed/22453918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350470
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