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Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase
Presenilin-1 (PS1) is the catalytic subunit of γ-secretase, and mutations in this protein cause familial Alzheimer Disease (FAD). However, little is known about how these mutations affect the active site of γ-secretase. Here, we show that PS1 mutations alter the S2 subsite within the active site of...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366784/ https://ncbi.nlm.nih.gov/pubmed/22461631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300483 |
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