γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have been implicated in the pathogenesis of Alzheimer disease. Small molecule γ-secretase modulators (GSMs) have emerged as potential disease-modifyi...

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Detalhes bibliográficos
Main Authors: Pozdnyakov, Nikolay, Murrey, Heather E., Crump, Christina J., Pettersson, Martin, Ballard, T. Eric, am Ende, Christopher W., Ahn, Kwangwook, Li, Yue-Ming, Bales, Kelly R., Johnson, Douglas S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617273/
https://ncbi.nlm.nih.gov/pubmed/23396974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398602
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