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Allele Specific p53 Mutant Reactivation
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the NCI anticancer drug screen data, we identified two compounds from the thiosemicarbazone family that manifest increased growth inhibitory activity in mutant p53 cells, particularly for the p53(R175) mu...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366694/ https://ncbi.nlm.nih.gov/pubmed/22624712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.042 |
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