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Synthesis of cyclic oligonucleotides by a modified phosphotriester approach.

Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxy...

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Détails bibliographiques
Auteurs principaux: de Vroom, E, Broxterman, H J, Sliedregt, L A, van der Marel, G A, van Boom, J H
Format: Artigo
Langue:Inglês
Publié: 1988
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC336652/
https://ncbi.nlm.nih.gov/pubmed/3380690
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