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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
Insulin-degrading enzyme (IDE), a Zn(2+)-metalloprotease, is involved in the clearance of insulin and amyloid-β (refs 1–3). Loss-of-function mutations of IDE in rodents cause glucose intolerance and cerebral accumulation of amyloid-β, whereas enhanced IDE activity effectively reduces brain amyloid-β...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366509/ https://ncbi.nlm.nih.gov/pubmed/17051221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05143 |
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