mTORC1 is essential for leukemia propagation but not stem cell self-renewal

Although dysregulation of mTOR complex 1 (mTORC1) promotes leukemogenesis, how mTORC1 affects established leukemia is unclear. We investigated the role of mTORC1 in mouse hematopoiesis using a mouse model of conditional deletion of Raptor, an essential component of mTORC1. Raptor deficiency impaired...

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Detalhes bibliográficos
Main Authors: Hoshii, Takayuki, Tadokoro, Yuko, Naka, Kazuhito, Ooshio, Takako, Muraguchi, Teruyuki, Sugiyama, Naoyuki, Soga, Tomoyoshi, Araki, Kimi, Yamamura, Ken-ichi, Hirao, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366413/
https://ncbi.nlm.nih.gov/pubmed/22622041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62279
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