Načítá se...

Plzf regulates germline progenitor self-renewal by opposing mTORC1

Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptor...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Hobbs, Robin M., Seandel, Marco, Falciatori, Ilaria, Rafii, Shahin, Pandolfi, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210556/
https://ncbi.nlm.nih.gov/pubmed/20691905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.041
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!