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Plzf regulates germline progenitor self-renewal by opposing mTORC1
Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptor...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210556/ https://ncbi.nlm.nih.gov/pubmed/20691905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.041 |
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