Llwytho...

Plzf regulates germline progenitor self-renewal by opposing mTORC1

Hyperactivity of mTORC1, a key mediator of cell growth, leads to stem cell depletion although the underlying mechanisms are poorly defined. Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs stem cell maintenance by a negative feedback from mTORC1 to receptor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hobbs, Robin M., Seandel, Marco, Falciatori, Ilaria, Rafii, Shahin, Pandolfi, Pier Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210556/
https://ncbi.nlm.nih.gov/pubmed/20691905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.041
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