SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD(+)-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD. However, the molecular signals underlying the p...

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Main Authors: Yao, Hongwei, Chung, Sangwoon, Hwang, Jae-woong, Rajendrasozhan, Saravanan, Sundar, Isaac K., Dean, David A., McBurney, Michael W., Guarente, Leonard, Gu, Wei, RÖnty, Mikko, Kinnula, Vuokko L., Rahman, Irfan
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366403/
https://ncbi.nlm.nih.gov/pubmed/22546858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60132
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