SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

Sirtuin1 (SIRT1), a protein/histone deacetylase, protects against the development of pulmonary emphysema. However, the molecular mechanisms underlying this observation remain elusive. The imbalance of tissue inhibitor of matrix metalloproteinases (TIMPs)/matrix metalloproteinases (MMPs) plays an imp...

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Main Authors: Yao, Hongwei, Hwang, Jae-woong, Sundar, Isaac K., Friedman, Alan E., McBurney, Michael W., Guarente, Leonard, Gu, Wei, Kinnula, Vuokko L., Rahman, Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840276/
https://ncbi.nlm.nih.gov/pubmed/24039251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00249.2012
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