TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

Itch, also known as pruritus, is a common, intractable symptom of several skin diseases, such as atopic dermatitis and xerosis. TLRs mediate innate immunity and regulate neuropathic pain, but their roles in pruritus are elusive. Here, we report that scratching behaviors induced by histamine-dependen...

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Detalhes bibliográficos
Main Authors: Liu, Tong, Berta, Temugin, Xu, Zhen-Zhong, Park, Chul-Kyu, Zhang, Ling, Lü, Ning, Liu, Qin, Liu, Yang, Gao, Yong-Jing, Liu, Yen-Chin, Ma, Qiufu, Dong, Xinzhong, Ji, Ru-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366391/
https://ncbi.nlm.nih.gov/pubmed/22565312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45414
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