Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

Although oligomeric β-amyloid (Aβ) has been suggested to have an important role in Alzheimer disease (AD), the mechanism(s) of how Aβ induces neuronal cell death has not been fully identified. The balance of pro- and anti-apoptotic Bcl-2 family proteins (e.g., Bcl-2 and Bcl-w versus Bad, Bim and Bax...

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Detalhes bibliográficos
Main Authors: Kudo, W, Lee, H-P, Smith, M A, Zhu, X, Matsuyama, S, Lee, H-g
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366077/
https://ncbi.nlm.nih.gov/pubmed/22592316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.43
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