Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

Failure to maintain protein homeostasis (proteostasis) leads to accumulation of unfolded proteins and contributes to the pathogenesis of many human diseases. Accumulation of unfolded proteins in the endoplasmic reticulum (ER) elicits unfolded protein response (UPR) that serves to attenuate protein t...

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Detalhes bibliográficos
Main Authors: Liu, Xian-De, Ko, Soyoung, Xu, Yi, Fattah, Elmoataz Abdel, Xiang, Qian, Jagannath, Chinnaswamy, Ishii, Tetsuro, Komatsu, Masaaki, Eissa, N. Tony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366003/
https://ncbi.nlm.nih.gov/pubmed/22518844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350934
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