Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins

Aberrant nonstop proteins arise from translation of mRNA molecules beyond the coding sequence into the 3′-untranslated region. If a stop codon is not encountered, translation continues into the poly(A) tail, resulting in C-terminal appendage of a polylysine tract and a terminally stalled ribosome. I...

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Vydáno v:J Biol Chem
Hlavní autoři: Crowder, Justin J., Geigges, Marco, Gibson, Ryan T., Fults, Eric S., Buchanan, Bryce W., Sachs, Nadine, Schink, Andrea, Kreft, Stefan G., Rubenstein, Eric M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513105/
https://ncbi.nlm.nih.gov/pubmed/26055716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663559
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