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Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

Glutamate transporter-1 (GLT-1) is the main glutamate transporter in the central nervous system, and its concentration severely decreases in neurodegenerative diseases. The number of transporters in the plasma membrane reflects the balance between their insertion and removal, and it has been reporte...

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Main Authors: García-Tardón, Noemí, González-González, Inmaculada M., Martínez-Villarreal, Jaime, Fernández-Sánchez, Enrique, Giménez, Cecilio, Zafra, Francisco
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365950/
https://ncbi.nlm.nih.gov/pubmed/22505712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355909
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