Liver-specific p70 S6 Kinase Depletion Protects against Hepatic Steatosis and Systemic Insulin Resistance

Obesity-associated hepatic steatosis is a manifestation of selective insulin resistance whereby lipogenesis remains sensitive to insulin but the ability of insulin to suppress glucose production is impaired. We created a mouse model of liver-specific knockdown of p70 S6 kinase (S6K) (L-S6K-KD) by sy...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bae, Eun Ju, Xu, Jianfeng, Oh, Da Young, Bandyopadhyay, Gautam, Lagakos, William S., Keshwani, Malik, Olefsky, Jerrold M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365775/
https://ncbi.nlm.nih.gov/pubmed/22493495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365544
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