Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Disruption of the Gys2 gene encoding the liver isoform of glycogen synthase generates a mouse strain (LGSKO) that almost completely lacks hepatic glycogen, has impaired glucose disposal, and is pre-disposed to entering the fasted state. This study investigated how the lack of liver glycogen increase...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Irimia, Jose M., Meyer, Catalina M., Segvich, Dyann M., Surendran, Sneha, DePaoli-Roach, Anna A., Morral, Nuria, Roach, Peter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481557/
https://ncbi.nlm.nih.gov/pubmed/28483921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786525
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