Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction

The role of serine palmitoyltransferase (SPT) and de novo ceramide biosynthesis in cardiac ceramide and sphingomyelin metabolism is unclear. To determine whether the de novo synthetic pathways, rather than ceramide uptake from circulating lipoproteins, is important for heart ceramide levels, we crea...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lee, Su-Yeon, Kim, Jung Ran, Hu, Yunying, Khan, Raffay, Kim, Su-Jung, Bharadwaj, Kalyani G., Davidson, Mercy M., Choi, Cheol-Soo, Shin, Kyong-Oh, Lee, Yong-Moon, Park, Woo-Jin, Park, In-Sun, Jiang, Xian-Cheng, Goldberg, Ira J., Park, Tae-Sik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Lipids
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365730/
https://ncbi.nlm.nih.gov/pubmed/22493506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296947
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