Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction

The role of serine palmitoyltransferase (SPT) and de novo ceramide biosynthesis in cardiac ceramide and sphingomyelin metabolism is unclear. To determine whether the de novo synthetic pathways, rather than ceramide uptake from circulating lipoproteins, is important for heart ceramide levels, we crea...

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Detalhes bibliográficos
Main Authors: Lee, Su-Yeon, Kim, Jung Ran, Hu, Yunying, Khan, Raffay, Kim, Su-Jung, Bharadwaj, Kalyani G., Davidson, Mercy M., Choi, Cheol-Soo, Shin, Kyong-Oh, Lee, Yong-Moon, Park, Woo-Jin, Park, In-Sun, Jiang, Xian-Cheng, Goldberg, Ira J., Park, Tae-Sik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365730/
https://ncbi.nlm.nih.gov/pubmed/22493506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296947
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