Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules

Cdc6 is the bifunctional AAA+ ATPase that assembles prereplicative complexes on origins of replication and activates p21(CIP1)- or p27(KIP1)-bound Cdk2. During the G(1)-S transition, the Cdc6 gene essential for chromosomal replication is activated by the E2F transcriptional factor. Paradoxically, Ap...

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Bibliografiske detaljer
Main Authors: Niimi, Shinichiro, Arakawa-Takeuchi, Shiho, Uranbileg, Baasanjav, Park, Jun-ha, Jinno, Shigeki, Okayama, Hiroto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365716/
https://ncbi.nlm.nih.gov/pubmed/22493447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347690
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