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Cdc6 Protein Activates p27(KIP1)-bound Cdk2 Protein Only after the Bound p27 Protein Undergoes C-terminal Phosphorylation
In mammalian cells Cdk2 activity during the G(1)-S transition is mainly controlled by p27(KIP1). Although the amount and subcellular localization of p27 influence Cdk2 activity, how Cdk2 activity is regulated during this phase transition still remains virtually unknown. Here we report an entirely ne...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307327/ https://ncbi.nlm.nih.gov/pubmed/22223646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318295 |
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