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Cdc6 Protein Activates p27(KIP1)-bound Cdk2 Protein Only after the Bound p27 Protein Undergoes C-terminal Phosphorylation

In mammalian cells Cdk2 activity during the G(1)-S transition is mainly controlled by p27(KIP1). Although the amount and subcellular localization of p27 influence Cdk2 activity, how Cdk2 activity is regulated during this phase transition still remains virtually unknown. Here we report an entirely ne...

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מידע ביבליוגרפי
Main Authors: Uranbileg, Baasanjav, Yamamoto, Hanako, Park, Jung-ha, Mohanty, Atish R., Arakawa-Takeuchi, Shiho, Jinno, Shigeki, Okayama, Hiroto
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307327/
https://ncbi.nlm.nih.gov/pubmed/22223646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318295
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