Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

α-Quaternary ketones are accessed through novel enantioselective alkylations of allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the presence of palladium complexes with various phosphinooxazoline (PHOX) ligands. Excellent yields and high enantiomeric excesses are...

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Main Authors: Behenna, Douglas C., Mohr, Justin T., Sherden, Nathaniel H., Marinescu, Smaranda C., Harned, Andrew M., Tani, Kousuke, Seto, Masaki, Ma, Sandy, Novák, Zoltán, Krout, Michael R., McFadden, Ryan M., Roizen, Jennifer L., Enquist, John A., White, David E., Levine, Samantha R., Petrova, Krastina V., Iwashita, Akihiko, Virgil, Scott C., Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365686/
https://ncbi.nlm.nih.gov/pubmed/22083969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201003383
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