Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

α-Quaternary ketones are accessed through novel enantioselective alkylations of allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the presence of palladium complexes with various phosphinooxazoline (PHOX) ligands. Excellent yields and high enantiomeric excesses are...

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Главные авторы: Behenna, Douglas C., Mohr, Justin T., Sherden, Nathaniel H., Marinescu, Smaranda C., Harned, Andrew M., Tani, Kousuke, Seto, Masaki, Ma, Sandy, Novák, Zoltán, Krout, Michael R., McFadden, Ryan M., Roizen, Jennifer L., Enquist, John A., White, David E., Levine, Samantha R., Petrova, Krastina V., Iwashita, Akihiko, Virgil, Scott C., Stoltz, Brian M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365686/
https://ncbi.nlm.nih.gov/pubmed/22083969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201003383
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