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DNA unwinding and inhibition of T4 DNA ligase by anthracyclines.
The ability to alter DNA tertiary structure of ten anthracycline derivatives whose antitumor potency is known was studied by an assay that makes use of nicked circular DNA and bacteriophage T4 DNA ligase. This assay allows the detection of tertiary structure alterations caused by DNA binding of both...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1988
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC336564/ https://ncbi.nlm.nih.gov/pubmed/3287337 |
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