Cargando...

DNA unwinding and inhibition of T4 DNA ligase by anthracyclines.

The ability to alter DNA tertiary structure of ten anthracycline derivatives whose antitumor potency is known was studied by an assay that makes use of nicked circular DNA and bacteriophage T4 DNA ligase. This assay allows the detection of tertiary structure alterations caused by DNA binding of both...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Montecucco, A, Pedrali-Noy, G, Spadari, S, Zanolin, E, Ciarrocchi, G
Formato: Artigo
Idioma:Inglês
Publicado: 1988
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC336564/
https://ncbi.nlm.nih.gov/pubmed/3287337
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!