Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

Cyclin-dependent kinase (Cdk)7, the catalytic subunit of the Cdk-activating kinase (CAK) complex has been implicated in the control of cell cycle progression and of RNA polymerase II (RNA pol II)-mediated transcription. Genetic inactivation of the Cdk7 locus revealed that whereas Cdk7 is completely...

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Main Authors: Ganuza, Miguel, Sáiz-Ladera, Cristina, Cañamero, Marta, Gómez, Gonzalo, Schneider, Ralph, Blasco, María A, Pisano, David, Paramio, Jesús M, Santamaría, David, Barbacid, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365431/
https://ncbi.nlm.nih.gov/pubmed/22505032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.94
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