Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

AIMS: Statins protect against cardiovascular-related mortality but induce skeletal muscle toxicity. To investigate mechanisms of statins, we tested the hypothesis that statins optimized cardiac mitochondrial function but impaired vulnerable skeletal muscle by inducing different level of reactive oxy...

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Detalhes bibliográficos
Main Authors: Bouitbir, Jamal, Charles, Anne-Laure, Echaniz-Laguna, Andoni, Kindo, Michel, Daussin, Frédéric, Auwerx, Johan, Piquard, François, Geny, Bernard, Zoll, Joffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365271/
https://ncbi.nlm.nih.gov/pubmed/21775390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehr224
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