Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

AIMS: Statins protect against cardiovascular-related mortality but induce skeletal muscle toxicity. To investigate mechanisms of statins, we tested the hypothesis that statins optimized cardiac mitochondrial function but impaired vulnerable skeletal muscle by inducing different level of reactive oxy...

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Detalles Bibliográficos
Main Authors: Bouitbir, Jamal, Charles, Anne-Laure, Echaniz-Laguna, Andoni, Kindo, Michel, Daussin, Frédéric, Auwerx, Johan, Piquard, François, Geny, Bernard, Zoll, Joffrey
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Clinical Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365271/
https://ncbi.nlm.nih.gov/pubmed/21775390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehr224
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