High Salt Intake Down-Regulates Colonic Mineralocorticoid Receptors, Epithelial Sodium Channels and 11β-Hydroxysteroid Dehydrogenase Type 2

Besides the kidneys, the gastrointestinal tract is the principal organ responsible for sodium homeostasis. For sodium transport across the cell membranes the epithelial sodium channel (ENaC) is of pivotal relevance. The ENaC is mainly regulated by mineralocorticoid receptor mediated actions. The MR...

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Hauptverfasser: Lienhard, Daniel, Lauterburg, Meret, Escher, Geneviève, Frey, Felix J., Frey, Brigitte M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365073/
https://ncbi.nlm.nih.gov/pubmed/22693583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037898
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